Editorial Proper cholesterol homeostasis requires a complex network of sterol-sensing proteins, membrane dynamics

and ex-tensive regulation of transcription, translation, posttranslation modifications, and protein turnover.1–3 Together, multilayered regulatory modules control 3 key processes to balance cellular cholesterol levels: de novo cholesterol biosynthesis, cholesterol uptake through lipoprotein receptors, and cholesterol efflux or excretion into bile.1,4,5 In addition to maintaining homeostasis, cholesterol efflux to lipid-poor apolipoprotein AI serves to form high-density lipoproteins (HDL) particles, which provide sys-temic cholesterol homeostasis through the reverse cholesterol transport pathway.6 The ATP-binding cassette transporter A1 (ABCA1) is a critical transporter of cholesterol and lipids from cells to extracellular apolipoprotein AI, a process that protects against cholesterol overload. ABCA1 expression is regulated by key nuclear receptors, namely the liver X receptor (LXR) fami