Glioblastoma multiforme (GBM) accounts for about 38 % of primary brain tumors in the United States. GBM is characterized by extensive angiogenesis induced by vascular growth factors and cytokines. The transcription of these growth factors and cytokines is regulated by the Hypoxia-Inducible-Factor-1(HIF-1), which is a key regulator mediating the cellular response to hypoxia. It is known that Factor Inhibiting HIF-1, or FIH-1, is also involved in the cellular response to hypoxia and has the capability to physically interact with HIF-1 and block its transcriptional activity under normoxic conditions. Delineation of the regulatory role of FIH-1 will help us to better understand the molecular mechanism responsible for tumor growth and progressio...
Inappropriate activation of the IGF (insulin-like growth factor) system has been implicated in the g...
Glioblastoma multiforme (GBM) is the most malignant variant of human glial tumors. A prominent featu...
Cellular adaptation to diminished tissue oxygen tensions, hypoxia, is largely governed by the hypoxi...
Glioblastoma multiforme (GBM) accounts for about 38% of primary brain tumors in the United States. G...
<div><p>Glioblastoma multiforme (GBM) accounts for about 38% of primary brain tumors in the United S...
Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the presen...
The tumour microenvironment (TME) is frequently hypoxic and inflammatory, leading to the activation ...
SummaryGlioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by gli...
Cell metabolism can be reprogrammed by tissue hypoxia leading to cell transformation and glioblastom...
SummaryThe hypoxia-inducible transcription factors HIF-1α and HIF-2α are activated in hypoxic tumor ...
INTRODUCTION: Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been sh...
In response to hypoxia during tumor growth, a number of genetic changes are induced that allow the c...
INTRODUCTION: Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been sh...
Background: Glioblastoma multiforme (GBM) is one of most common and still poorly treated primary bra...
Aim: Improved treatment strategies are desperately needed for eradicating cancer stem cells (CSCs), ...
Inappropriate activation of the IGF (insulin-like growth factor) system has been implicated in the g...
Glioblastoma multiforme (GBM) is the most malignant variant of human glial tumors. A prominent featu...
Cellular adaptation to diminished tissue oxygen tensions, hypoxia, is largely governed by the hypoxi...
Glioblastoma multiforme (GBM) accounts for about 38% of primary brain tumors in the United States. G...
<div><p>Glioblastoma multiforme (GBM) accounts for about 38% of primary brain tumors in the United S...
Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the presen...
The tumour microenvironment (TME) is frequently hypoxic and inflammatory, leading to the activation ...
SummaryGlioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by gli...
Cell metabolism can be reprogrammed by tissue hypoxia leading to cell transformation and glioblastom...
SummaryThe hypoxia-inducible transcription factors HIF-1α and HIF-2α are activated in hypoxic tumor ...
INTRODUCTION: Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been sh...
In response to hypoxia during tumor growth, a number of genetic changes are induced that allow the c...
INTRODUCTION: Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been sh...
Background: Glioblastoma multiforme (GBM) is one of most common and still poorly treated primary bra...
Aim: Improved treatment strategies are desperately needed for eradicating cancer stem cells (CSCs), ...
Inappropriate activation of the IGF (insulin-like growth factor) system has been implicated in the g...
Glioblastoma multiforme (GBM) is the most malignant variant of human glial tumors. A prominent featu...
Cellular adaptation to diminished tissue oxygen tensions, hypoxia, is largely governed by the hypoxi...