Add to ORKGThe objective of this investigation was to characterize the phar-macokinetic/pharmacodynamic correlation of buprenorphine and fentanyl for the antinociceptive effect in rats. Data on the time course of the antinociceptive effect following intravenous administration of buprenorphine or fentanyl was analyzed in conjunction with plasma concentrations by nonlinear mixed-effects analysis. For fentanyl, the pharmacokinetics was de-scribed on the basis of a two-compartment pharmacokinetic model. For buprenorphine, a three-compartment pharmacoki-netic model best described the concentration time course. To explain time dependencies in pharmacodynamics of buprenor-phine and fentanyl, a combined effect compartment/receptor binding model was applied. A...
Ketamine is a glutamate N-methyl-D-aspartate receptor antagonist that is a rapid-acting dissociative...
Abstract Background Illicitly manufactured fentanyl and its analogs are a major ...
BACKGROUND: Buprenorphine is used as an analgesic for postoperative and chronic pain. The usual subl...
Background: The objective of this investigation was to characterize the pharmacokinetic-pharmacodyna...
The objective of the investigations described in this thesis was to characterize the in vivo pharmac...
The purpose of the study was to investigate placebo and buprenorphine effects on event-related poten...
Pharmacokinetic (PK) and pharmacodynamic (PD) data were available from a study of a nasal delivery s...
The purpose of the study was to investigate placebo and buprenorphine effects on event-related poten...
jpet.aspetjournals.org D ow nloaded from JPET #82560 running title: PK/PD of buprenorphine and fenta...
Pain is characterized by its multi-dimensional nature, explaining in part why the pharmacokinetic/ph...
The aim of this study was to develop population pharmacokinetic-pharmacodynamic models for morphine ...
The relationships between plasma or brain concentrations and analgesic effects of both buprenorphine...
The objective of this investigation was to characterize the phar-macokinetic-pharmacodynamic (PK-PD)...
Buprenorphine (Bup) is an opioid analgesic that is commonly used in laboratory rodents to provide po...
Using a modelling approach, this study aimed to (i) examine whether the pharmacodynamics of the anal...
Ketamine is a glutamate N-methyl-D-aspartate receptor antagonist that is a rapid-acting dissociative...
Abstract Background Illicitly manufactured fentanyl and its analogs are a major ...
BACKGROUND: Buprenorphine is used as an analgesic for postoperative and chronic pain. The usual subl...
Background: The objective of this investigation was to characterize the pharmacokinetic-pharmacodyna...
The objective of the investigations described in this thesis was to characterize the in vivo pharmac...
The purpose of the study was to investigate placebo and buprenorphine effects on event-related poten...
Pharmacokinetic (PK) and pharmacodynamic (PD) data were available from a study of a nasal delivery s...
The purpose of the study was to investigate placebo and buprenorphine effects on event-related poten...
jpet.aspetjournals.org D ow nloaded from JPET #82560 running title: PK/PD of buprenorphine and fenta...
Pain is characterized by its multi-dimensional nature, explaining in part why the pharmacokinetic/ph...
The aim of this study was to develop population pharmacokinetic-pharmacodynamic models for morphine ...
The relationships between plasma or brain concentrations and analgesic effects of both buprenorphine...
The objective of this investigation was to characterize the phar-macokinetic-pharmacodynamic (PK-PD)...
Buprenorphine (Bup) is an opioid analgesic that is commonly used in laboratory rodents to provide po...
Using a modelling approach, this study aimed to (i) examine whether the pharmacodynamics of the anal...
Ketamine is a glutamate N-methyl-D-aspartate receptor antagonist that is a rapid-acting dissociative...
Abstract Background Illicitly manufactured fentanyl and its analogs are a major ...
BACKGROUND: Buprenorphine is used as an analgesic for postoperative and chronic pain. The usual subl...