Hodgkin's Disease in Homosexual Men with Generalized Lymphadenopathy

pathy not attributable to an identifiable cause in h o m o-sexual men was first described in 1982 ( 1). Biopsy samples of the enlarged lymph nodes have shown a char-acteristic pattern of follicular or paracortical hyperplasia, or both ( 2, 3). These studies have suggested that this unexplained lymphadenopathy in homosexual men, the lymphadenopathy syndrome, may be part of the spec-trum of the acquired immunodeficiency syndrome. W e have recently noted Hodgkin's disease developing in patients with the lymphadenopathy syndrome. This finding is provocative because Hodgkin's disease and the lymphadenopathy syndrome are both associated with cel-lular immunodeficiencies ( 4- 6). A l so, these disorders have similar clinical presentations, which presents a diag-nostic di lemma