Editorial The Riddle of Nonsustained Ventricular Tachycardia and Sudden Cardiac Death Are We Approaching a Solution?

The graveyard of cardiovascular therapeutics is litteredwith common-sense ideas. Premature ventricular con-tractions trigger episodes of ventricular fibrillation; therefore, suppression of premature ventricular contractions should lessen the risk of cardiac arrest and sudden death–and yet it has not.1–2 Sudden cardiac death (SCD), which is responsible for between 184 000 and 450 000 deaths in the United States per year,3–6 remains a conundrum, both in prevention and prediction of those at risk. The epidemiology of SCD presents challenges for clinical care; patients who are in the known highest-risk subgroups, such as those with abnormal systolic left ventricular function, account for the minority of events.7 Even among this high-risk subgroup with a mortality benefit afforded by implant-able cardioverter defibrillator (ICD) placement, the majority of implanted patients never require therapy for arrhythmic events from the device.8–9 This actuality emphasizes the need to bette