doi: 10.11648/j.js.20140203.11 Elevated liver enzymes in patients with cholecystitis

Abstract: Aims: To investigate changes in liver function tests in calcular cholecystitis (acute and chronic) and to relate that changes to cholecystitis. Methods: A retrospective study including 389 patients with clinical and sonographic evidence of cholecystitis with exclusion of other causes of elevated liver function tests, which are done preoperatively and four weeks postoperatively. Results: Increased liver function tests observed in both acute and chronic cholecystitis. The only significant differences between both groups were a higher bilirubin level (P = 0.001) and WBC (P = 0.018). Pre and post-cholecystectomy levels of AST, ALK-P and GGT were significantly changed (P = 0.001). Conclusion: Our study showed that the abnormal biochemical liver function tests resolved rapidly and spontaneously after cholecystectomy indicating transient hepatocellular injury with cholecystitis