BIOL i~YC},:IATRY 1991:30:205-209 Sleep Onset REM Periods in Schizophremc Patients

Sleep EEG studies in depression have consis-tently shown shortened rapid-eye-movement (REM) iatem;y in m~y patients (Kupfer et al 1986), with a smaller subset expe~encing sleep-onset REM (SOREM), defined as the onset of REM within 10-20 rain of the onset of sleep. In depression, SOREMs have been associated with greater illness severity (Reynolds et a