Imaging the Absolute Configuration of a Chiral Epoxide in the Gas Phase

In chemistry and biology, chirality, or handedness, refers to molecules that exist in two spatial configurations that are incongruent mirror images of one another. Almost all biologically active molecules are chiral, and the correct determination of their absolute configuration is essential for the understanding and the development of processes involving chiral molecules. Anomalous x-ray diffraction and vibrational optical activity measurements are broadly used to determine absolute configurations of solid or liquid samples. Determining absolute configurations of chiral molecules in the gas phase is still a formidable challenge. Here we demonstrate the determination of the absolute configuration of isotopically labeled (R,R)-2,3-dideuterooxirane by foil-induced Coulomb explosion imaging of individual molecules. Our technique provides unambiguous and direct access to the absolute configuration of small gas-phase species, including ions and molecular fragments. In1847, Louis Pasteur realized that crystals oftartaric acid can come in two different shapes,which are nonsuperimposable mirror images of one another. He was able to sort them and dis-solve them separately, and he found that the re-spective liquids rotate the axis of linearly polarize