Cytolytic T Lymphocytes Specific for Tumors and Infected Cells from Mice with a Retrovirus-Induced Immunodeficiency Syndrome

LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors. Recently, several laboratories have described a general-ized immunodeficiency syndrome in susceptible mouse strains following infection by a murine retrovirus isolate termed LP-BM5 (20, 24, 25), that originated from the Du-plan-Latarjet isolate (19) of murine leukemia virus (MuLV). The LP-BM5 isolate is a complex mixture of MuLV includ-ing ecotropic, mink cell focus-inducing, and defective vi-ruses; currently it is generally agreed that the defectiv