www.hetjournal.com Commentary Can hormesis be a default for dose-response?

Since the 1920s, interest in hormesis has peaked and ebbed. Hormesis had been a forgotten theory until recent investigation by Dr Ed Calabrese at the University of Massachusetts, along with others, resurrected it from obscurity. This renewed interest is demonstrated by recent articles in prestigious scientific journals such as Nature and Science as well as the popular press (Discovery, US News and World Report and newspapers The previous five articles explore whether hormesis applies to a variety of chemicals a high enough percentage of times to allow it to become a default for traditional dose-response. In many cases, a beneficient effect at low dose will dip the dose-response curve about 30%, imparting a U or J shape to the overall curve. In some cases, 30 % can have