Determination of Gold in Drugs and Serum by Use of Anodic Stripping Voltammetry

Gold is determined in aqueous gold-containing drug solutions, 8 X 108 to 1 X 10 mol/liter, and in such drugs in serum, 2 X 106 to 1 X 10 mol/ liter, by electrodeposition onto a carbon paste elec-trode at-0.3 V vs. a saturated calomel electrode and subsequent stripping at constant current. Aque-ous solutions are prepared for electrodeposition with a ceric perchlorate-hydrogen peroxide treatment. Serum samples are in addition treated with nitric and chloric acids. Variation coefficients are 16 to 2.5%, depending on concentration and deposition time. Additional Keyphrases: arthritis treatment #{149}chronopo-tentiometric detection #{149}drug assay #{149}toxicology Gold salts are frequently used in the treatment of arthritis (1). Three drugs are currently on the mar