Add to ORKGMutations in the mitochondrial protein kinase PINK1 are associ-ated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity both directly via phosphorylation of Parkin serine 65 (Ser65)—which lies within its ubiquitin-like domain (Ubl)—and indirectly through phosphorylation of ubiquitin at Ser65. How Ser65-phosphorylated ubiquitin (ubiquitinPhospho-Ser65) contributes to Parkin activation is currently unknown. Here, we demonstrate that ubiquitinPhospho-Ser65 binding to Parkin dramatically increases the rate and stoichiometry of Parkin phosphorylation at Ser65 by PINK1 in vitro. Analysis of the Parkin structure, corroborated by site-directed mutagenesis, shows that the ...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in the mitochondrial protein kinase PINK1 are associ-ated with autosomal recessive Parkins...
Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinso...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in the mitochondrial protein kinase PINK1 are associ-ated with autosomal recessive Parkins...
Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinso...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture a...