Add to ORKGBackground: Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatment. However, some patients remain virologically suppressed despite suboptimal adherence. We hypothesized that this could result from host genetic factors influencing drug levels. Methods: Eligible individuals were Caucasians treated with efavirenz (EFV) and/or boosted lopinavir (LPV/r) with self-reported poor adherence, defined as missing doses of ART at least weekly for more than 6 months. Participants were genotyped for single nucleotide polymorphisms (SNPs) in candidate genes previously reported to decrease EFV (rs3745274, rs35303484, rs35979566 in CYP2B6) and LPV/r clearance (rs4149056 in SLCO1B1, rs6945984 in CYP3A, rs717620 in ABCC2)
†<p>Reference group for analyses is those with reference allele. Genetic results available in 86% of...
BACKGROUND:We hypothesized that the percent adherence to antiretroviral therapy necessary to maintai...
BACKGROUND: Efavirenz (EFV) based antiretroviral therapy is expanding worldwide. However discontinua...
Background Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatmen...
Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatment. However, so...
BACKGROUND: Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatment....
Background. High rates of second-line antiretroviral treatment (ART) failure are reported. The assoc...
The aim of this study was to assess the correlation between the estimated adherence of HIV-1 infecte...
The aim of this study was to assess the correlation between the estimated adherence of HIV-1 infecte...
AbstractBackgroundEfavirenz (EFV) based antiretroviral therapy is expanding worldwide. However disco...
Background:A benchmark of near-perfect adherence ( 6595%) to antiretroviral therapy (ART) is often c...
Background. Modern antiretroviral therapy (ART) regimens are widely assumed to be forgivable to mode...
BACKGROUND:HIV-1-infected patients vary considerably by their response to antiretroviral treatment, ...
We hypothesized that the percent adherence to antiretroviral therapy necessary to maintain HIV suppr...
BACKGROUND: High rates of second-line antiretroviral treatment (ART) failure are reported. The assoc...
†<p>Reference group for analyses is those with reference allele. Genetic results available in 86% of...
BACKGROUND:We hypothesized that the percent adherence to antiretroviral therapy necessary to maintai...
BACKGROUND: Efavirenz (EFV) based antiretroviral therapy is expanding worldwide. However discontinua...
Background Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatmen...
Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatment. However, so...
BACKGROUND: Good adherence to antiretroviral therapy (ART) is critical for successful HIV treatment....
Background. High rates of second-line antiretroviral treatment (ART) failure are reported. The assoc...
The aim of this study was to assess the correlation between the estimated adherence of HIV-1 infecte...
The aim of this study was to assess the correlation between the estimated adherence of HIV-1 infecte...
AbstractBackgroundEfavirenz (EFV) based antiretroviral therapy is expanding worldwide. However disco...
Background:A benchmark of near-perfect adherence ( 6595%) to antiretroviral therapy (ART) is often c...
Background. Modern antiretroviral therapy (ART) regimens are widely assumed to be forgivable to mode...
BACKGROUND:HIV-1-infected patients vary considerably by their response to antiretroviral treatment, ...
We hypothesized that the percent adherence to antiretroviral therapy necessary to maintain HIV suppr...
BACKGROUND: High rates of second-line antiretroviral treatment (ART) failure are reported. The assoc...
†<p>Reference group for analyses is those with reference allele. Genetic results available in 86% of...
BACKGROUND:We hypothesized that the percent adherence to antiretroviral therapy necessary to maintai...
BACKGROUND: Efavirenz (EFV) based antiretroviral therapy is expanding worldwide. However discontinua...