FJ. Antigen microarrays for the study of autoimmune diseases. Clin Chem

BACKGROUND: The immune response involves the activa-tion of heterogeneous populations of T cells and B cells that show different degrees of affinity and specificity for target antigens. Although several techniques have been developed to study the molecular pathways that control immunity, there is a need for high-throughput assays to monitor the specificity of the immune response. CONTENT: Antigen microarrays provide a new tool to study the immune response.We reviewed the literature on antigen microarrays and their advantages and limi-tations, and we evaluated their use for the study of au-toimmune diseases. Antigen arrays have been success-fully used for several purposes in the investigation of autoimmune disorders: for disease diagnosis, to mon-itor disease progression and response to therapy, t