Comparative Analysis of the Interaction of Helicobacter pylori with

Helicobacter pylorimay cause chronic gastritis, gastric cancer, or lymphoma. Myeloid antigen-presenting cells (APCs) are most likely involved in the induction and expression of the underlying inflammatory responses. To study the interaction of human APC subsets withH. pylori, we infected monocytes, monocyte-derived dendritic cells (DCs), and monocyte-derived (classically activated; M1) macrophages withH. pylori and analyzed phenotypic alterations, cytokine secretion, phagocytosis, and immuno-stimulation. Since we detected CD163 (alternatively activated; M2) macrophages in gastric biopsy specimens fromH. pylori-positive patients, we also included monocyte-derived M2macrophages in the study. UponH. pylori infection, monocytes se