072 ASSOCIATION OF OBSTRUCTIVE SLEEP APNOEA (OSA) WITH INCIDENT STROKE: A SYSTEMATIC REVIEW AND META–ANALYSIS

Background The relationship between obstructive sleep apnoea (OSA) and stroke remains unclear. We conducted a systematic review to determine the incident risk of stroke among patients with OSA. Methods and Results We searched MEDLINE and EMBASE for prospective studies that followed up patients with OSA (and controls) for over 12 months for incident stroke. Outcomes data were pooled using random effects meta–analysis and heterogen-eity assessed with the I2 statistic. Regression analysis was performed to quantify the effects of OSA severity (using the apnoea–hypopnea index). For meta–analysis we identified 5 relevant studies from 1731 citations;1–5 4 were adjusted for other stroke risk factors.1–4. OSA was associated with incident stroke (8435 participants), odds ratio (OR) 2.24; 95 % confi-dence interval (CI), 1.57–3.19; I2=7%. A significant associatio