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Long Term Evolution (LTE) Release 8 of the Universal Mobile Telecommunications Systems (UMTS) was developed to provide extensive support for deployment in a variety of spectrum allocations, ranging from 1.4 MHz to 20 MHz, for both paired and unpaired bands. For system bandwidth beyond 20 MHz, the only reasonable way to achieve LTE-Advanced highest target peak-throughput rate is to increase the transmission bandwidth, relative to Release 8. In order to provide the necessary bandwidth, LTE-Advanced specifies spectrum allocations of up to 100 MHz using “carrier aggregation”, where multiple component carriers are combined. Therefore, to configure all component carriers that are LTE Release 8 compatible, at least when the aggregated numbers of component carriers in the Uplink (UL) and the Downlink (DL) must be the same. However, not all component carriers are necessarily Release 8 compatible. The main aim of this paper is to investigate a comprehensive analysis of physical layer throughput of LTE-Advanced (DL) and (UL) using Multi Input Multi Output channel (MIMO) 2x2 based on standard parameters for different channel bandwidths. Keyword: LTE-Advance