The pharmacokinetics of ofloxacin and a review of its tissue penetration

The pharmacokinetics of ofloxacin were studied in six healthy volunteers following a 600 mg oral dose. The concentration of the compound was measured in serum, inflammatory fluid and urine. Ofloxacin was rapidly absorbed, the mean maximum concentration of ofloxacin being 10·7 rngjl at 1·2 h. The mean serum elimination half-life was 7 hand 80·3 % of the administered compound was recovered in the urine by 48 h. Ofloxacin penetrated the inflammatory fluid well, the mean peak level being 5·2 mg/l at 5·3 h. A review of the tissue penetration is presented which indicates that the high volume of distribution of ofloxacin is associated with good tissue penetration