Forskolin directly stimulates adenylate cyclase activity and acts synergistically with receptor-mediated agonists which stimulate cyclic AMP production. We have previously observed that a 3-hr incubation of C6-2B rat astrocytoma cells with 6 nM cholera toxin in the presence of 1 M forskolin results in cyclic AMP accumulation 9-fold greater than in the absence of forskolin. Since the action ofcholera toxin is mediated by the stimulatory guanine nucleotide-binding regulatory component (G5) of the adenylate cyclase complex, we proposed that the mechanism by which forskolin augments hormone responses involves an enhanced coupling of G5 with the adenylate cyclase catalytic component (C). In the present communication, we report the detailed chara...
Cholera toxin, through adenylate cyclase activation reproduced cyclic AMP-mediated effects of thyroi...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Forskolin, a potent activator of adenylate cyclase, has been proposed to activate this enzyme by a d...
AbstractForskolin is a potent activator of the cyclic AMP-generating system in many tissues. In dog ...
The novel adenylate cyclase activator forskolin caused rapid and high intracellular accumulation of ...
Because some responses to forskolin are adenosine 3',5'-cyclic phosphate (cyclic AMP) independent, w...
The regulation of the insulin receptor by cAMP has been examined in glial C6 cells. Incubation for 4...
An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Cholera toxin, through adenylate cyclase activation reproduced cyclic AMP-mediated effects of thyroi...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Forskolin, a potent activator of adenylate cyclase, has been proposed to activate this enzyme by a d...
AbstractForskolin is a potent activator of the cyclic AMP-generating system in many tissues. In dog ...
The novel adenylate cyclase activator forskolin caused rapid and high intracellular accumulation of ...
Because some responses to forskolin are adenosine 3',5'-cyclic phosphate (cyclic AMP) independent, w...
The regulation of the insulin receptor by cAMP has been examined in glial C6 cells. Incubation for 4...
An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Cholera toxin (CT) catalyses ADP-ribosylation of the alpha-subunit of stimulatory protein (Gs) leadi...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Cholera toxin, through adenylate cyclase activation reproduced cyclic AMP-mediated effects of thyroi...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation o...