STATISTICAL VOXEL-WISE ANALYSIS OF ICTAL SPECT REVEALS PATTERN OF ABNORMAL PERFUSION IN PATIENTS WITH TEMPORAL LOBE EPILEPSY

ABSTRACT- O b j e c t i v e: To investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion SPECT images (BSI) from patients with temporal lobe epilepsy (TLE). Method: It was acquired interictal and ictal BSI from 24 patients with re f r a c t o ryTLE. BSIs were analyzed by visual inspection and statistical parametric mapping (SPM2). Statistical analysis compared the patients group to a control gro u p of 50 volunteers. The images from patients with left-TLE were left-right flipped. Results: It was not ob-s e rved significant perfusional diff e rences in interictal scans with SPM. Ictal BSI in SPM analysis revealed hy-p e r p e rfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipi-tal region, ipsilateral posterior cingulate gyrus, occipital lobes and ipsilateral basal ganglia. Ictal BSI als