and the International Collaboration on Endocarditis Merged Database Study Groupa

Background. Staphylococcus aureus native valve infective endocarditis (SA-NVIE) is not completely understood. The objective of this investigation was to describe the characteristics of a large, international cohort of patients with SA-NVIE. Methods. The International Collaboration on Endocarditis Merged Database (ICE-MD) is a combination of 7 existing electronic databases from 5 countries that contains data on 2212 cases of definite infective endocarditis (IE). Results. Of patients with native valve IE, 566 patients (34%) had IE due to S. aureus, and 1074 patients had IE due to pathogens other than S. aureus (non–SA-NVIE). Patients with S. aureus IE were more likely to die (20% vs. 12%;), to experience an embolic event (60 % vs. 31%;), or to have a central nervous systemP!.001 P!.001 event (20 % vs. 13%; ) and were less likely to undergo surgery (26 % vs. 39%; ) than were patientsP!.001 P!.001 with non–SA-NVIE. Multivariate analysis of prognostic factors of mortality identified age (odds ratio [OR], 1.4