The parts contributed by the author in recent discussions with several physicists and mathematicians are reviewed, as they have been occasioned by the 2006 book "The Trouble with Physics", of Lee Smolin. Some of the issues addressed are the possible and not yet sufficiently explored relationship between modern Mathemat-ics and theoretical Physics, as well as the way physicists may benefit from becoming more aware of what at present appear to be certain less than fortunate yet essential differences between modern Mathematics and theoretical Physics, as far as the sig-nificant freedom of introducing new fundamental concepts, structures and theories in the former is concerned. A number of modern mathematical concepts and struc-tures ...