An Unusual Balanced Reciprocal Translocation in Several Members of a Family

Chromosome abnormalities in structure as well as number have often been found to be associated with congenital anomalies in humans. Numerous gene-tic mechanisms have been postulated to explain the cytogenetic alterations. Wallace and Anderson (1964) reported a patient with numerous congenital anomalies whose chro-mosomal analysis revealed 45 chromosomes with a translocation deletion involving members of the D and B Groups. Bray and Ann Josephine (1964) described an infant with severe mental and physical retardation whose karyotype comprised 46 chromo-somes with an unusually long B chromosome and suggested that it represented a translocation involv-ing members ofthe B andD groups ofchromosomes