Add to ORKGDuring replication, DNA damage can challenge replication fork progression and cell viability. Homologous Recombination (HR) and Translesion Synthesis (TLS) pathways appear as major players involved in the resumption and completion of DNA replication. How both pathways are coordinated in human cells to maintain genome stability is unclear. Numerous helicases are involved in HR regulation. Among them, the helicase FBH1 accumulates at sites of DNA damage and potentially constrains HR via its anti-recombinase activity. However, little is known about its regulation in vivo. Here, we report a mechanism that controls the degradation of FBH1 after DNA damage. Firstly, we foun
<b>Background</b>\ud \ud Maintenance of genome stability is critical in human cells. Mutations in or...
<div><p>Homologous recombination (HR) is crucial for the error-free repair of DNA double-strand brea...
Replicative DNA helicases expose the two strands of the double helix to the replication apparatus, b...
During replication, DNA damage can challenge replication fork progression and cell viability. Homolo...
The genome is constantly threatened by various damaging agents and maintaining its integrity is cruc...
Degradation of helicases or helicase-like proteins, often mediated by ubiquitin-proteasomal pathways...
Proper resolution of stalled replication forks is essential for genome stability. Purification of FB...
The progression of replication forks can be slowed down or paused by various external and internal f...
DNA replication fork perturbation is a major challenge to the maintenance of genome integrity. It ha...
Homologous recombination is involved in the repair of DNA damage and collapsed replication fork, and...
SummaryDNA replication fork perturbation is a major challenge to the maintenance of genome integrity...
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefor...
Controlling the loading of Rad51 onto DNA is important for governing when and how homologous recombi...
DNA double-strand breaks are toxic lesions, which jeopardize the genomic integrity and survival of a...
DNA replication is mediated by a multi-protein complex known as the replisome. With the hexameric MC...
<b>Background</b>\ud \ud Maintenance of genome stability is critical in human cells. Mutations in or...
<div><p>Homologous recombination (HR) is crucial for the error-free repair of DNA double-strand brea...
Replicative DNA helicases expose the two strands of the double helix to the replication apparatus, b...
During replication, DNA damage can challenge replication fork progression and cell viability. Homolo...
The genome is constantly threatened by various damaging agents and maintaining its integrity is cruc...
Degradation of helicases or helicase-like proteins, often mediated by ubiquitin-proteasomal pathways...
Proper resolution of stalled replication forks is essential for genome stability. Purification of FB...
The progression of replication forks can be slowed down or paused by various external and internal f...
DNA replication fork perturbation is a major challenge to the maintenance of genome integrity. It ha...
Homologous recombination is involved in the repair of DNA damage and collapsed replication fork, and...
SummaryDNA replication fork perturbation is a major challenge to the maintenance of genome integrity...
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefor...
Controlling the loading of Rad51 onto DNA is important for governing when and how homologous recombi...
DNA double-strand breaks are toxic lesions, which jeopardize the genomic integrity and survival of a...
DNA replication is mediated by a multi-protein complex known as the replisome. With the hexameric MC...
<b>Background</b>\ud \ud Maintenance of genome stability is critical in human cells. Mutations in or...
<div><p>Homologous recombination (HR) is crucial for the error-free repair of DNA double-strand brea...
Replicative DNA helicases expose the two strands of the double helix to the replication apparatus, b...