Regulatory Variants for the Expression of H-2 Antigens. II. Level of Discrimination of

SUMMARY-We used alloantigenic variants to analyze whether killer T-cells and antibody in the presence of complement (two effector components of the immune system) recognized the same determinants on target tissues. The variants were se-lected from mouse myeloma cells by immune selection and differed from the parent cell in that they did not express H·2 antigens. The results suggested that both killer T-cells and hu-moral effectors recognized the.sarne determinants, though the killer T-cells may have been more sensitive either in recogniz-ing these determinants or mediating Iysis.-J Natl Cancer Inst 56: 1229-1231, 1976. By subjecting mouse myeloma cells repeatedly to selec-tion with antibody against H-2 antigen in the presence of complement, we isolated variant clones resistant to immune cytolysis (1). As indicated by their resistance t