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This research explores the interaction effect of terminology and source credibility on communication effectiveness between prevention-focused and promotion-focused individuals. Results reveal that communication messages containing terminologies are more effective than those containing no terminologies for promotion-focused individuals, whereas messages containing no terminologies are more effective than those containing terminologies for prevention-focused individuals. Furthermore, messages containing terminologies endorsed by either a high- or a low-credibility source are more effective than those containing no terminology information for promotion-focused individuals. However, for prevention-focused individuals, communication messages containing terminol-ogies endorsed by a highly credible source are more effective than those containing no terminology information. Alternatively, communication messages containing no terminology information are more effective than those containing terminol-ogies endorsed by a low credible source. One of the most important tasks for communication mes-sages is to form a positive attitude change or lead to effective communication. Considerable research attention has been devoted to understanding the effects of source credibility on communication effectiveness (Petty & Wegener, 1998; Pornpitakpan, 2004). Generally, source credibility can affect communication effectiveness through a variety of distinct mechanisms, depending on how message recipients process the communicationmessages. Research on source credibility has been limited mostly to scale development (e.g., Lafferty, Goldsmith & Newell, 2002; Ohanian, 1990) and the impact of source credibility on consumer reactions to advertisements (e.g., Goldberg &amp