BASIC BIOLOGICAL SCIENCES IgG Subclasses in Human Periodontal Disease: III. Serum Concentrations of IgG Subclass Immunoglobulins and Circulating Immune Complexes

No quantitative changes in serum IgG subclass concentrations could be correlated clinically with periodontal disease, despite evidence of restrictive IgG subclass antibody responses in inflamed gingiva. Serum from periodontal patients also lacked circulating immune complexes. J Dent Res 58(7):1701-1704, July 1979 Introduction. Immunopathological studies have shown that, as human inflammatory periodontal disease progresses, the nature of the cellular infiltrates change.1,2,3 The mild gingiviti