Cholangiofibrosis is a structural anomaly that precedes the development of cholangiocarcinoma in some rodent models. In this article, the authors examine the contribution of the epithelial and mesenchymal cells in the pathogenesis of this complex lesion. Furan was administered to rats by gavage in corn oil at 30 mg/kg b.w. (five daily doses per week) and livers were sampled between eight hr to three months. Characteristically the administration of furan caused centrilobular injury, and restoration was accomplished by proliferation of hepatocytes. Some areas of the liver were, however, more severely affected, and here, injury extended into portal and capsular areas, which resulted in a rapid proliferation of ductular cells that extended into...
Subject headings liver cirrhosis/pathology; liver cirrhosis/etiology; liver cirrhosis/ physio...
Objective: Bile duct ligation (BDL), chronic liver injury model, was extensively used in studying me...
Background & Aims: Activation of hepatic stellate cells (HSC) and transdifferentiation to myofibrobl...
Rodent studies have shown that furan is a hepatocarcinogen. Previous studies conducted with high dos...
Ductular cell proliferation induced by various chemical carcinogens and its sequences in the exper...
Two important signaling pathways in liver fibrosis are the PDGF- and TGFβ pathway and compounds inhi...
The cholangipathies are a class of liver diseases that specifically affects the biliary tree. These ...
ObjectiveTo compare serum biochemical parameters, liver pathology, and fibronectin (FN) expression i...
Two important signaling pathways in liver fibrosis are the PDGF- and TGFb pathway and compounds inhi...
Two important signaling pathways in liver fibrosis are the PDGF-and TGF beta pathway and compounds i...
Objective. To test the effects of peginterferon in an unrecoverable model of bile-duct ligation (BDL...
Background: Many chronic liver diseases lead to progressive hepatic fibrosis, a condition that can u...
Animal models of hepatic fibrosis provide a means to study the cell and molecular mediators of fibro...
Background: One of the most useful experimental fibrogenesis models is the bile duct-ligated rats. O...
International audienceHepatic fibrosis, the major complication of virtually all types of chronic liv...
Subject headings liver cirrhosis/pathology; liver cirrhosis/etiology; liver cirrhosis/ physio...
Objective: Bile duct ligation (BDL), chronic liver injury model, was extensively used in studying me...
Background & Aims: Activation of hepatic stellate cells (HSC) and transdifferentiation to myofibrobl...
Rodent studies have shown that furan is a hepatocarcinogen. Previous studies conducted with high dos...
Ductular cell proliferation induced by various chemical carcinogens and its sequences in the exper...
Two important signaling pathways in liver fibrosis are the PDGF- and TGFβ pathway and compounds inhi...
The cholangipathies are a class of liver diseases that specifically affects the biliary tree. These ...
ObjectiveTo compare serum biochemical parameters, liver pathology, and fibronectin (FN) expression i...
Two important signaling pathways in liver fibrosis are the PDGF- and TGFb pathway and compounds inhi...
Two important signaling pathways in liver fibrosis are the PDGF-and TGF beta pathway and compounds i...
Objective. To test the effects of peginterferon in an unrecoverable model of bile-duct ligation (BDL...
Background: Many chronic liver diseases lead to progressive hepatic fibrosis, a condition that can u...
Animal models of hepatic fibrosis provide a means to study the cell and molecular mediators of fibro...
Background: One of the most useful experimental fibrogenesis models is the bile duct-ligated rats. O...
International audienceHepatic fibrosis, the major complication of virtually all types of chronic liv...
Subject headings liver cirrhosis/pathology; liver cirrhosis/etiology; liver cirrhosis/ physio...
Objective: Bile duct ligation (BDL), chronic liver injury model, was extensively used in studying me...
Background & Aims: Activation of hepatic stellate cells (HSC) and transdifferentiation to myofibrobl...