Add to ORKGAdditional genetic aberrations apart from KIT D816V are found in advanced systemic mastocytosis. Additional genetic aberrations apart from KIT D816V are associated with a significant reduction of overall survival. To explore mechanisms contributing to the clinical heterogeneity of systemic mastocy-tosis (SM) and to suboptimal responses to diverse therapies, we analyzed 39 KIT D816V mutated patients with indolent SM (n 5 10), smoldering SM (n 5 2), SM with associated clonal hematologic nonmast cell lineage disorder (SM-AHNMD, n5 5), and aggressive SM (n5 15) ormast cell leukemia (n5 7) with (n5 18) or without (n5 4) AHNMD for additional molecular aberrations. We applied next-generation sequencing to investigate ASXL1
Mastocytosis comprises rare heterogeneous diseases characterized by an increased accumulation of abn...
Mastocytosis is a rare hematological neoplasm characterized by the proliferation of abnormal clonal ...
We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new molecular def...
To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis (SM) and t...
Most patients with KIT D816V+ advanced systemic mastocytosis (SM) are characterized by somatic mutat...
Systemic mastocytosis (SM) is a rare clonal haematopoietic stem cell disease in which activating KIT...
Systemic mastocytosis (SM) is a highly heterogeneous disease with indolent and aggressive forms, wit...
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mas...
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mas...
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mas...
BACKGROUND Systemic mastocytosis (SM) is a heterogenous, clonal mast cell (MC) proliferation, rarely...
KIT D816 mutations (KIT D816(mut)) are strongly associated with systemic mastocytosis (SM) but are a...
The activating KIT D816V mutation plays a central role in the pathogenesis, diagnosis, and targeted ...
Mastocytosis comprises rare heterogeneous diseases characterized by an increased accumulation of abn...
Mastocytosis is a rare hematological neoplasm characterized by the proliferation of abnormal clonal ...
We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new molecular def...
To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis (SM) and t...
Most patients with KIT D816V+ advanced systemic mastocytosis (SM) are characterized by somatic mutat...
Systemic mastocytosis (SM) is a rare clonal haematopoietic stem cell disease in which activating KIT...
Systemic mastocytosis (SM) is a highly heterogeneous disease with indolent and aggressive forms, wit...
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mas...
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mas...
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mas...
BACKGROUND Systemic mastocytosis (SM) is a heterogenous, clonal mast cell (MC) proliferation, rarely...
KIT D816 mutations (KIT D816(mut)) are strongly associated with systemic mastocytosis (SM) but are a...
The activating KIT D816V mutation plays a central role in the pathogenesis, diagnosis, and targeted ...
Mastocytosis comprises rare heterogeneous diseases characterized by an increased accumulation of abn...
Mastocytosis is a rare hematological neoplasm characterized by the proliferation of abnormal clonal ...
We hypothesized that analysis of single nucleotide polymorphism arrays (SNP-A) and new molecular def...