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With the discovery of many economic, environmental, and health problems in sealed and mechanically ventilated buildings, the concept of natural ventilation has been revived. "Buildings that breathe " have become more and more desired by ordinary people and architects. Although natural ventilation is conceptually simple, it is difficult to design and control. At present, methods to study natural ventilation are either inaccurate or costly. This study aims at solving these problems by using large eddy simulation (LES). In LES, a three-dimensional, time-dependent method, the contribution of the large, energy-carrying structures is computed directly and only the smallest scales of turbulence are modeled. This investigation has identified a filtered dynamic subgrid-scale model of LES to study natural ventilation. The experimental data from a wind tunnel, a full-scale test chamber, and other research data have been used to validate the LES program. Methods have been developed to solve the problems encountered in validating LES models for natural ventilation studies. Studying the characteristics of different indoor and outdoor airflows helps to identify the best SGS model for those flows. By comparing th