volume 10 Number 18 1982 Nucleic Acids Research Structure and evolution of the heavy chain from rat immunogtobuHn E

The nucleotide sequence of the rat e-chain mRNA has been determined by sequencing cloned cDNA copies of the mRNA. The established sequence covers the coding region, the 3'-non coding region and most of the 5 ' non-coding region. A comparison with the nucleotide sequence of the human e-chain constant region reveals that Cj and C4 are the most highly conserved domains. The rat e-chain contains a C-terminal decapeptide which is not present in the human counterpart