ALTERED RESPONSE TO SMALL DOSES OF INSULIN ASSOCIATED WITH ELECTROPLEXY AND HYPOGLYCAEMIC THERAPIES * BY

The measurement of response to insulin utilizes a number of qualitative and quantitative variables. For example, in the treatment of diabetes there are varying criteria as to what constitutes satisfactory control of the disorder, whereas with deep insulin treatment for schizophrenia in which the end-point is the production of coma, the variables include the definition of coma, the degree of resistance to the drug, and the possibility that the nervous system of each individual treated shows its own selective susceptibility to insulin as it does to many other drugs (Kalinowsky and Hoch, 1952). Fortunately, the response to small doses of insulin can be determined more precisely by the use of the insulin tolerance test, and the results reporte