To define critical parameters concerning interferon (IFN) effects upon natural killer (NK) cells in vivo, we gave cancer patients serial weekly intramuscular injections of purified lymphoblastoid IFN in six doses ranging from 105 to 3 X 10 ' U. Dose sequences were determined by randomly allocating patients to one of six levels in a latin square ordering scheme. NK cell stimulation, a threefold peak increase above preinjection levels of cytolysis (P = 0.022), occurred in peripheral mononuclear cells (PMC) sampled 24 h postinjection, of 3 X 106 U, but was not detectable at any dose in PMC sampled 7 d postinjection. No blunting occurred in NK cell responsiveness to repeated injection of IFN dosages a second time at or several weeks after ...
BACKGROUND: Natural killer cells are an important component of the innate immune system. Anti-cancer...
Natural killer (NK) cells are lymphocytes of the innate immune system and have the ability to kill t...
The use of an IFN-γ ELISPOT assay to evaluate cellular immune responses has gained increasing popula...
An enriched population of human natural killer (NK) cells was obtained by density gradient centrifug...
<p>A—Analysis of NK-cell cytotoxicity following NK-cell activation with TLR9-stimulated pDCs in cont...
The present study was designed to test whether immunomodulating doses of human beta-interferon would...
Interferons comprise a class of structurally related proteins which exert several regulatory effects...
<p>(A) Deficient NK cell cytotoxicity from IT patients. NK cell cytotoxicity was assessed in primary...
Natural killer (NK) cells have an intrinsic ability to detect and eliminate leukaemic cells. Cellula...
Reduced natural killer cell activity was observed in patients with oral leukoplakia and submucous fi...
The growth of tumors induced by inoculation of cells transformed by Moloney sarcoma virus can be inh...
A good correlation was found between in vivo and in vitro responses of peripheral MNC from breast ca...
Mouse YAC-1 and human K562 leukemic cells were treated in vitro with fibroblast interferon (IF) and ...
Background & Aims: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular...
<p>Increasing the killing frequency of fresh NK cells by cytokines and Rituximab. (A) Freshly isolat...
BACKGROUND: Natural killer cells are an important component of the innate immune system. Anti-cancer...
Natural killer (NK) cells are lymphocytes of the innate immune system and have the ability to kill t...
The use of an IFN-γ ELISPOT assay to evaluate cellular immune responses has gained increasing popula...
An enriched population of human natural killer (NK) cells was obtained by density gradient centrifug...
<p>A—Analysis of NK-cell cytotoxicity following NK-cell activation with TLR9-stimulated pDCs in cont...
The present study was designed to test whether immunomodulating doses of human beta-interferon would...
Interferons comprise a class of structurally related proteins which exert several regulatory effects...
<p>(A) Deficient NK cell cytotoxicity from IT patients. NK cell cytotoxicity was assessed in primary...
Natural killer (NK) cells have an intrinsic ability to detect and eliminate leukaemic cells. Cellula...
Reduced natural killer cell activity was observed in patients with oral leukoplakia and submucous fi...
The growth of tumors induced by inoculation of cells transformed by Moloney sarcoma virus can be inh...
A good correlation was found between in vivo and in vitro responses of peripheral MNC from breast ca...
Mouse YAC-1 and human K562 leukemic cells were treated in vitro with fibroblast interferon (IF) and ...
Background & Aims: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular...
<p>Increasing the killing frequency of fresh NK cells by cytokines and Rituximab. (A) Freshly isolat...
BACKGROUND: Natural killer cells are an important component of the innate immune system. Anti-cancer...
Natural killer (NK) cells are lymphocytes of the innate immune system and have the ability to kill t...
The use of an IFN-γ ELISPOT assay to evaluate cellular immune responses has gained increasing popula...