VASCULAR BIOLOGY RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute

The receptor for advanced glycation end products (RAGE) contributes to the inflam-matory response in many acute and chronic diseases. In this context, RAGE has been identified as a ligand for the 2-integrin Mac-1 under static in vitro conditions. Be-cause intercellular adhesion molecule (ICAM)-1 also binds2-integrins, we studied RAGE/, Icam1/, and RAGE/ Icam1/ mice to define the relative contribution of each ligand for leukocyte adhesion in vivo. We show that trauma-induced leukocyte ad-hesion in cremaster muscle venules is strongly dependent on RAGE and ICAM-1 acting together in an overlapping fashion