BIOINFORMATICS APPLICATIONS NOTE doi:10.1093/bioinformatics/bts554 Databases and ontologies Advance Access publication September 12, 2012 An RNA Mapping DataBase for curating RNA structure mapping experiments

Summary: We have established an RNA mapping database (RMDB) to enable structural, thermodynamic and kinetic comparisons across single-nucleotide-resolution RNA structure mapping experiments. The volume of structure mapping data has greatly increased since the development of high-throughput sequencing techniques, accelerated software pipelines and large-scale mutagenesis. For scientists wishing to infer relationships between RNA sequence/structure and these mapping data, there is a need for a database that is curated, tagged with error estimates and interfaced with tools for sharing, visu-alization, search and meta-analysis. Through its on-line front-end, the RMDB allows users to explore single-nucleotide-resolution mapping data in heat-map, bar-graph and colored secondary structure graph-ics; to leverage these data to generate secondary structure hypoth-eses; and to download the data in standardized and computer-friendly files, including the RDAT and community-consensus SNRNASM for-mats. At the time of writing, the database houses 53 entries, describ-ing more than 2848 experiments of 1098 RNA constructs in several solution conditions and is growing rapidly