Analysis of a large number of data on cytochrome P450 (P450) in-hibition obtained from quantitative high-throughput screening assays from the PubChem BioAssay Database clearly indicates that mo-lecular size has an important activity-limiting role for datasets fo-cused on drug-like compounds (PubChem BioAssay Identifier [AID] 1851) as well as for datasets also incorporating a wider range o
The results of qualitative structure-activity relationship (QSAR) analysis are reported for several ...
Critical evaluation of the published literature showed that there are considerable variations in the...
Molecular profiling efforts aim at characterizing the biological actions of small molecules by scree...
The cytochrome P450s (CYPs) play a central role in the metabolism of various endogenous and exogenou...
This study presents an analysis of the small molecule bioactivity profiles across large quantities o...
This study presents an analysis of the small molecule bioactivity profiles across large quantities o...
Cytochromes P450 (CYP) are a superfamily of enzymes, involved in metabolism of xenobiotic compounds....
This work provides an analysis of across-target bioactivity results in the screening data deposited ...
Includes bibliographical references.Cytochrome P450 (CYPs) are a superfamily of heme containing enzy...
Semi-automated high throughput screening for the inhibition of major human cytochrome P450 enzymes (...
Three-dimensional homology models of cytochromes P450 (P450) 2B1 and P450 3A4 have been utilized alo...
Cytochrome P450 (P450) reaction phenotyping is a key process toward accurately determining the contr...
Publicly available compound and bioactivity databases provide an essential basis for data-driven app...
Molecular profiling efforts aim at characterizing the biological actions of small molecules by scree...
In this dissertation, I present several strategies to leverage experimental data towards a quantitat...
The results of qualitative structure-activity relationship (QSAR) analysis are reported for several ...
Critical evaluation of the published literature showed that there are considerable variations in the...
Molecular profiling efforts aim at characterizing the biological actions of small molecules by scree...
The cytochrome P450s (CYPs) play a central role in the metabolism of various endogenous and exogenou...
This study presents an analysis of the small molecule bioactivity profiles across large quantities o...
This study presents an analysis of the small molecule bioactivity profiles across large quantities o...
Cytochromes P450 (CYP) are a superfamily of enzymes, involved in metabolism of xenobiotic compounds....
This work provides an analysis of across-target bioactivity results in the screening data deposited ...
Includes bibliographical references.Cytochrome P450 (CYPs) are a superfamily of heme containing enzy...
Semi-automated high throughput screening for the inhibition of major human cytochrome P450 enzymes (...
Three-dimensional homology models of cytochromes P450 (P450) 2B1 and P450 3A4 have been utilized alo...
Cytochrome P450 (P450) reaction phenotyping is a key process toward accurately determining the contr...
Publicly available compound and bioactivity databases provide an essential basis for data-driven app...
Molecular profiling efforts aim at characterizing the biological actions of small molecules by scree...
In this dissertation, I present several strategies to leverage experimental data towards a quantitat...
The results of qualitative structure-activity relationship (QSAR) analysis are reported for several ...
Critical evaluation of the published literature showed that there are considerable variations in the...
Molecular profiling efforts aim at characterizing the biological actions of small molecules by scree...
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