Dynamic Article Links ► ARTICLE TYPE This journal is © The Royal Society of Chemistry [year] [journal], [year], [vol], 00–00 | 1 Highly Regioselective Nitrile Oxide Dipolar Cycloadditions with ortho-

The dipolar cylcoadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent 10 functionalization of the isoxazole scaffold has been demonstrated. Isoxazoles serve as a valuable class of heterocyclic structures found in natural products and medicinally relevant compounds. Pinho e Melo has written a recent detailed review 15 of the synthesis and reactivity of isoxazoles.1 This functional group is generally constructed via two major methods – condensation of hydroxylamine with a 1,3-dicarbonyl compound and cycloaddition of an alkyne with a nitrile oxide.2 The cycloaddition strategy is of particular interest to 20 our laboratory.3,