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In this article I examine the intersection between sexuality and spirit-filled bodies in American Evangelicalism. I am interested in investi-gating two issues: the sexual body as a site of spiritual battle and the use of popular science, especially the domain of genetics, as material evidence for this spiritual warfare. Specifically, I trace the increasingly spiritualized framing of marital intercourse in evangelical literature. To follow this trajectory, I highlight the spiritualized dangers of transgres-sive sexuality as well as the sexualizing of spirituality in evangelical sex manuals and deliverance manuals. This article centers around one text, Holy Sex: God’s Purpose and Plan for Our Sexuality, whose authors’ contend that sexually transmitted diseases are, in fact, demons lodged in genetic material that can be transferred through body fluids and bloodlines. The assertions about biology and demonic affliction made throughout the book are extreme and would be rejected by mos