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Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Objective. Endoscopic sinus surgery (ESS) for chronic rhinosi-nusitis (CRS) may be compromised by postoperative inflam-mation, polyposis, and adhesions, often requiring subsequent intervention. To address this issue, the authors investigated the safety and effectiveness of controlled delivery of mometa-sone furoate to the sinus mucosa via bioabsorbable implants deployed at the time of ESS. Study Design. Prospective, multicenter, randomized, controlled, double-blind trial using an intrapatient control design. Setting. Otolaryngology–head and neck surgery centers; both academic and private practices. Subjects and Methods. The study enrolled 105 patients wit