Letters to the Editor

Mutation analysis of the methyl-CpG binding protein 2 gene (MECP2) in patients with Rett syndrome EDITOR—Rett syndrome (RTT, MIM 312760) is a neurodevelopmental disorder characterised by normal early psychomotor development followed by a period of regression, the loss of acquired purposeful manual and speech skills, hand wringing, gait disturbance, and growth retardation.1 As RTT occurs exclusively in females and almost all patients with RTT are sporadic, it has been pro-posed that RTT is caused by an X linked dominant muta-tion with lethality in hemizygous males.1 Recently, DNA mutations in the methyl-CpG binding protein 2 gene (MECP2), mapped to Xq28, have been detected in some patients with RTT.2 3 We carried out a mutation analysis i