D3(25-OH-D3) was studied in primary cultures of pul-monary alveolar macrophages (PAM) from seven pa-tients with sarcoidosis and two patients with idiopathic pulmonary fibrosis. Production of a [3H]1,25-dihy-droxyvitamin D3 (1,25-[OH]2-D3)-like metabolite of [3H]25-OH-D3 was detected in lipid extracts of cells from five patients with sarcoidosis. Synthesis of this compound in vitro was limited to viable PAM and was greatest in cells derived from a patient with hyper-calcemia and an elevated serum concentration of 1,25-dihydroxyvitamin D. The tritiated PAM metabolite coeluted with authentic 1,25-(OH)2-D3 in three differ-ent solvent systems on straight-phase high performance liquid chromatography (HPLC) and demonstrated binding to extracted re...
The peripheral blood monocyte (PBM) migrates into tissues and differentiates into mature tissue macr...
Macrophages produce various arachidonic acid (AA) metabolites which may either enhance or suppress i...
It has been well established that human mononuclear phagocytes have the capacity to produce 1,25-dih...
Phagocytic cells are widely distributed in tissues known to be important in the metabolism of vitami...
AbstractThe metabolism of 25-hydroxyvitamin D3 [25(OH)D3] was examined in several phagocytic cells i...
Metabolism of 25-OH-vitamin D3 by peritoneal macrophages from CAPD patients. The active metabolite o...
Identification of 25-hydroxyvitamin D3 1α-hydroxylase gene expression in macrophages.BackgroundThe 2...
Macrophages synthesize active vitamin D (1,25-dihydroxy-vitamin D) and express the vitamin D recepto...
AbstractMetabolism of 25-[3H]hydroxyvitamin D3 was studied in peritoneal macrophages from renal fail...
SummaryBackgroundActive vitamin D metabolite, 1, 25-dihydroxyvitamin D, has pleomorphic effects on b...
The hypercalcemia of various granulomatoses is caused by endogenous 1,25-dihydroxyvitamin D [1,25-(O...
Abstract: Alveolar macrophages acquire lα‐hydroxylase activity in inflammation, and thereby metaboli...
It has been well established that human mononuclear phagocytes have the capacity to produce 1,25-dih...
We studied superoxide anion (O2) generation by alveolar macrophages (AM) isolated from bronchoalveol...
U937 is a human-derived lymphoma cell line that has monoblastic properties and high-affinity recepto...
The peripheral blood monocyte (PBM) migrates into tissues and differentiates into mature tissue macr...
Macrophages produce various arachidonic acid (AA) metabolites which may either enhance or suppress i...
It has been well established that human mononuclear phagocytes have the capacity to produce 1,25-dih...
Phagocytic cells are widely distributed in tissues known to be important in the metabolism of vitami...
AbstractThe metabolism of 25-hydroxyvitamin D3 [25(OH)D3] was examined in several phagocytic cells i...
Metabolism of 25-OH-vitamin D3 by peritoneal macrophages from CAPD patients. The active metabolite o...
Identification of 25-hydroxyvitamin D3 1α-hydroxylase gene expression in macrophages.BackgroundThe 2...
Macrophages synthesize active vitamin D (1,25-dihydroxy-vitamin D) and express the vitamin D recepto...
AbstractMetabolism of 25-[3H]hydroxyvitamin D3 was studied in peritoneal macrophages from renal fail...
SummaryBackgroundActive vitamin D metabolite, 1, 25-dihydroxyvitamin D, has pleomorphic effects on b...
The hypercalcemia of various granulomatoses is caused by endogenous 1,25-dihydroxyvitamin D [1,25-(O...
Abstract: Alveolar macrophages acquire lα‐hydroxylase activity in inflammation, and thereby metaboli...
It has been well established that human mononuclear phagocytes have the capacity to produce 1,25-dih...
We studied superoxide anion (O2) generation by alveolar macrophages (AM) isolated from bronchoalveol...
U937 is a human-derived lymphoma cell line that has monoblastic properties and high-affinity recepto...
The peripheral blood monocyte (PBM) migrates into tissues and differentiates into mature tissue macr...
Macrophages produce various arachidonic acid (AA) metabolites which may either enhance or suppress i...
It has been well established that human mononuclear phagocytes have the capacity to produce 1,25-dih...