ESSENTIAL HYPERTENSION: INBORN ERROR OF SODIUM METABOLISM?

THE NATURE of essential hypertension remains largely a matter of controversy and conjecture. The title of ithis paper is one such conjecture, and it is controversial. Our selection and presentation of material will be tinted by this; readers desiring related but more compre-hensive and more impartial reviews might turn to Tobian '(1960) or Dahl (1963). Salt-induced Hypertension in Rats The history of NaCl-induced hypertension in rats is given iby Meneely and 'Dahl (1961). In our laboratory iwe now have two strains of white Sprague-Dawley rats, both with fairly predictable prognosis relative to the develop-ment of hypertension, (Dahl, Heine and Tas