ARTICLE NO. 0131 4-Methylthiobenzoic Acid Protection against Cisplatin Nephrotoxicity:

This study investigates the changes in renal antioxidant system after cisplatin administration and the nephroprotection with 4-methylthiobenzoic acid (MTBA). Male Wistar rats were injected with (1) vehicle control, (2) cisplatin, (3) MTBA, and (4) cisplatin plus MTBA. Rats were euthenized 3 days post-treatment and kid-ney was isolated and analyzed for platinum concentration, malon-dialdehyde (MDA), glutathione (GSH and GSSG), superoxide dis-mutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Plasma creatinine increased 508 % following cisplatin admin-istration alone, which decreased to 189 % with MTBA. Cisplatin-treated rats showed a depletion of renal GSH levels (53%), while cisplatin plus MTBA-injected rats had GSH values close to those of the controls. SOD, CAT, and GSH-Px activities decreased 36, 29, and 38%, respectively, and MDA levels increased 212 % follow-ing cisplatin administration, which were restored to control level