Cell intercalation and cell shape changes drive noto-chord morphogenesis in the African frog, Xenopus laevis. Experimental observations show that cells elongate mediolaterally and intercalate between one another, causing the notochord to lengthen and narrow. Descriptive observations provide few clues as to the mechanisms that coordinate and drive these cell movements. It is possible that a few rules governing cell behavior could orchestrate the shaping of the entire tissue. We test this hypothesis by constructing a computer model of the tissue to investigate how rules governing cell motility and cell-cell interactions can account for the major features of notochord morphogen-esis. These rules are drawn from the literature on in vitro cell s...
Early on in development, embryos undergo a dramatic change in shape in order to transform from a col...
AbstractDuring gastrulation, the vertebrate embryo is patterned and shaped by complex signaling path...
Embryonic development involves a fundamental biomechanical process that constructs complicated three...
The vertebrate embryo\u27s first organ is the notochord, a stiffening rod later replaced by the back...
The vertebrate embryo’s first organ is the notochord, a stiffening rod later replaced by the backbon...
AbstractIn this study we investigate the induction of the cell behaviors underlying neurulation in t...
The notochord is a conserved axial structure that in vertebrates serves as a hydrostatic scaffold fo...
International audienceWe present a theoretical model of animal morphogenesis construed as a self-org...
AbstractOrchestrated cell movements marshalled by proper cell polarity in the developing body axes a...
Embryonic tissues are shaped by the dynamic behaviours of their constituent cells. To understand suc...
AbstractDishevelled signaling plays a critical role in the control of cell intercalation during conv...
In a companion paper (Shih, J. and Keller, R. (1992) Development 116, 901–914), we described a seque...
AbstractWe compared the type and patterning of morphogenic cell behaviors driving convergent extensi...
We discuss the cellular basis and tissue interactions regulating convergence and extension of the v...
AbstractGastrulation is a dynamic tissue-remodeling process occurring during early development and f...
Early on in development, embryos undergo a dramatic change in shape in order to transform from a col...
AbstractDuring gastrulation, the vertebrate embryo is patterned and shaped by complex signaling path...
Embryonic development involves a fundamental biomechanical process that constructs complicated three...
The vertebrate embryo\u27s first organ is the notochord, a stiffening rod later replaced by the back...
The vertebrate embryo’s first organ is the notochord, a stiffening rod later replaced by the backbon...
AbstractIn this study we investigate the induction of the cell behaviors underlying neurulation in t...
The notochord is a conserved axial structure that in vertebrates serves as a hydrostatic scaffold fo...
International audienceWe present a theoretical model of animal morphogenesis construed as a self-org...
AbstractOrchestrated cell movements marshalled by proper cell polarity in the developing body axes a...
Embryonic tissues are shaped by the dynamic behaviours of their constituent cells. To understand suc...
AbstractDishevelled signaling plays a critical role in the control of cell intercalation during conv...
In a companion paper (Shih, J. and Keller, R. (1992) Development 116, 901–914), we described a seque...
AbstractWe compared the type and patterning of morphogenic cell behaviors driving convergent extensi...
We discuss the cellular basis and tissue interactions regulating convergence and extension of the v...
AbstractGastrulation is a dynamic tissue-remodeling process occurring during early development and f...
Early on in development, embryos undergo a dramatic change in shape in order to transform from a col...
AbstractDuring gastrulation, the vertebrate embryo is patterned and shaped by complex signaling path...
Embryonic development involves a fundamental biomechanical process that constructs complicated three...