Add to ORKGAims Endothelial cells (ECs) control vascular permeability by forming a monolayer that is sealed by extracellular junctions. Various mediators modulate the endothelial barrier by acting on junctional protein complexes and the therewith con-nected F-actin cytoskeleton. Different Rho GTPases participate in this modulation, but their mechanisms are still partly resolved. Here, we aimed to elucidate whether the opening and closure of the endothelial barrier are asso-ciated with distinct localized RhoA activities at the subcellular level. Methods and results Live fluorescence resonance energy transfer (FRET) microscopy revealed spatially distinct RhoA activities associate
The bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins...
In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been develo...
<p>(A) RhoA, Rac1 or Cdc42 were silenced in HUVECs using 100 nM siRNA for 72 hours, and the cell lys...
<div><p>Compromised endothelial barrier function is a hallmark of inflammation. Rho family GTPases a...
Compromised endothelial barrier function is a hallmark of inflammation. Rho family GTPases are criti...
During immune surveillance and inflammation, leukocytes exit the vasculature through transient openi...
RhoGTPases are known regulators of intracellular actin dynamics that are important for maintaining e...
The small GTPase RhoA is involved in cell morphology and migration. RhoA activity is tightly regulat...
Endothelial barrier dysfunction underlies chronic inflammatory diseases. In searching for new protei...
ABSTRACT Activation of the Rho GTPase pathway determines endothelial cell (EC) hyper-permeability af...
The small GTPase RhoA is involved in cell morphology and migration. RhoA activity is tightly regulat...
In the present study, the roles of the small GTPase RhoA and its target Rho kinase in endothelial pe...
Endothelial cells (ECs) line all blood vessels and dynamically regulate the endothelial barrier func...
Endothelial cells line the vasculature and are important for the regulation of blood pressure, vascu...
The bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins...
The bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins...
In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been develo...
<p>(A) RhoA, Rac1 or Cdc42 were silenced in HUVECs using 100 nM siRNA for 72 hours, and the cell lys...
<div><p>Compromised endothelial barrier function is a hallmark of inflammation. Rho family GTPases a...
Compromised endothelial barrier function is a hallmark of inflammation. Rho family GTPases are criti...
During immune surveillance and inflammation, leukocytes exit the vasculature through transient openi...
RhoGTPases are known regulators of intracellular actin dynamics that are important for maintaining e...
The small GTPase RhoA is involved in cell morphology and migration. RhoA activity is tightly regulat...
Endothelial barrier dysfunction underlies chronic inflammatory diseases. In searching for new protei...
ABSTRACT Activation of the Rho GTPase pathway determines endothelial cell (EC) hyper-permeability af...
The small GTPase RhoA is involved in cell morphology and migration. RhoA activity is tightly regulat...
In the present study, the roles of the small GTPase RhoA and its target Rho kinase in endothelial pe...
Endothelial cells (ECs) line all blood vessels and dynamically regulate the endothelial barrier func...
Endothelial cells line the vasculature and are important for the regulation of blood pressure, vascu...
The bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins...
The bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins...
In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been develo...
<p>(A) RhoA, Rac1 or Cdc42 were silenced in HUVECs using 100 nM siRNA for 72 hours, and the cell lys...