Abnormal morphology Bleeding

EWRR abstracts Background Nailfold videocapillaroscopy (NFC), allows for the detection of changes in microcirculation. In the granulomatosis with polyangiitis (GPA) the existence of a defined pattern has not been found. Objectives The main objective of our study was to detect the pos-sible existence of a defined pattern in the microcirculation of the nailfold capillaries of patients with GPA. The second objective was to investigate the possible correlation between abnormalities found and systemic involvement. Methods We identified 10 patients with a current mean age of 55.7 ± 16.5 years and predominantly female (60%). The mean age at diagnosis was 49.4 years. 70 % had upper respiratory tract involve-ment, the same percentage had pulmonary involvement (cavitated nodules or alveolar haemorrhage), the cutaneous manifestations such as purpura or necrotic ulcers were present in 70%. About 40% had renal involvement (renal failure, proliferative glomerulonephri-tis), and 40 % had peripheral neurological involvement. NFC was carried out by the same rheumatologist, on fingers 3 through to 5 of both hands using a ZUZI videocapillaroscopy, trinocular, dual illu-mination and zoom of 1 X 4 X. Results Abnormalities of the microcirculation of nailfold capillar-ies were found in 8 of the 10 patients. Among the patients with this pathological microcirculation, 62.5 % had structural alterations (tor-tuous capillaries), 50 % presented with micro-haemorrhage (single or multiple), avascular areas were found in 37.5 % and 75 % showed lower capillary density. Neither capillary dilation nor the formation of new vessels were detected within the sample of patients. Abstract A6.7 Table 1 Correlation between capilaroscopic finding with organ involvemen