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Magnetic Resonance Imaging (MRI) has been established as a primary imaging module in clinical practices because of its high spatial resolution and richness in soft tissue contrast. However, the mainstream clinical application of MRI is currently dominated by the qualitative reading approach. Advanced quantitative approaches, such as Dynamic Contrast Enhanced MRI (DCE-MRI) or MR relaxometry, provide more objective information about tissue component and function, which can be essential to improve the accuracy and efficiency of disease diagnosis, treatment plan design, and drug effect monitoring. Several studies had been conducted to explore techniques that can be used to improve various quantitative MRI approaches in clinical-related context. The results were summarized in this text. Pharmacokinetic analysis of DCE-MRI data is an important method to assess pathophysiological permeability changes in cancerous tissue with abnormal angiogenesis. A modified two-compartment pharmacokinetic model was proposed, based on more realistic model assumptions. Pharmacokinetic parameters derived with this model were demonstrated to have better tissue specificity in distinguishing metastatic tumor fro