Add to ORKGOur objective was to study acquired Activated Protein C (APC) resistance in patients with antiphospholipid antibodies (aPL) using a thrombin generation based assay. We compared patients with and without lupus (systemic lupus erythematosus, SLE). A parameter summar-izing APC inhibition of thrombin generation with increasing APC concentrations (IC50-APC) was increased in all patient groups compared to controls: median values were 15.3 (interquar-tile range, IQR, 9.7 to 34.0) in patients with primary antiphospholipid syndrome (APS), 27.3 (IQR 23.5 to 43.5) in patients with SLE without APS, 64.1 (IQR 25.9 to 65.0) in patients with SLE/APS compared to 10.4 [IQR 8.5 to 15.8] in controls, respectively p 0.003, p 0.0001 and p 0.0001. In conclusi...
APS is an acquired prothrombotic state associated with antiphospholipid antibodies namely anticardio...
Background: Antibodies binding to domain I of beta(2)-glycoprotein I (aDI) and activated protein C (...
Nojima et al (2002) recently reported the co-existence of lupus anticoagulant (LA) and anti-prothrom...
The antiphospholipid syndrome is characterized by the occurrence of vascular thrombosis combined wit...
OBJECTIVES: Risk factors for thromboembolism in SLE are poorly understood. We hypothesized a possibl...
Anticardiolipin antibodies (aCL), anti-b2-glycoprotein I (b2GPI) antibodies and lupus antic-oagulant...
Antiphospholipid syndrome (APS) is a hypercoagulable state accompanied by the presence of heterogene...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Antiphospholipid syndrome (APS) is associated with thrombotic events (tAPS) and/or obstetrical morbi...
Background Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antico...
Antibodies against b2-glycoprotein I (anti-b2GPI) are one of the hallmarks of the antipho-spholipid ...
In patients with lupus anticoagulants (LA), acquired resistance to activated protein C (APC) is diff...
APS is an acquired prothrombotic state associated with antiphospholipid antibodies namely anticardio...
Background: Antibodies binding to domain I of beta(2)-glycoprotein I (aDI) and activated protein C (...
Nojima et al (2002) recently reported the co-existence of lupus anticoagulant (LA) and anti-prothrom...
The antiphospholipid syndrome is characterized by the occurrence of vascular thrombosis combined wit...
OBJECTIVES: Risk factors for thromboembolism in SLE are poorly understood. We hypothesized a possibl...
Anticardiolipin antibodies (aCL), anti-b2-glycoprotein I (b2GPI) antibodies and lupus antic-oagulant...
Antiphospholipid syndrome (APS) is a hypercoagulable state accompanied by the presence of heterogene...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antic...
Antiphospholipid syndrome (APS) is associated with thrombotic events (tAPS) and/or obstetrical morbi...
Background Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus antico...
Antibodies against b2-glycoprotein I (anti-b2GPI) are one of the hallmarks of the antipho-spholipid ...
In patients with lupus anticoagulants (LA), acquired resistance to activated protein C (APC) is diff...
APS is an acquired prothrombotic state associated with antiphospholipid antibodies namely anticardio...
Background: Antibodies binding to domain I of beta(2)-glycoprotein I (aDI) and activated protein C (...
Nojima et al (2002) recently reported the co-existence of lupus anticoagulant (LA) and anti-prothrom...