1 BRONCHIAL NITRIC OXIDE IS RELATED TO SYMPTOM RELIEF DURING FLUTICASONE TREATMENT IN COPD

High levels of exhaled nitric oxide (NO) predict favorable response to inhaled corticosteroids in asthma, but the ability of exhaled NO or inflammatory markers in exhaled breath condensate (EBC) to predict steroid-responsiveness in COPD is not known. We measured alveolar and bronchial NO output, levels of leukotriene B4 (LTB4), cysteinyl leukotrienes (cysLTs) and 8-isoprostane in EBC, spirometry, body plethysmography and symptoms in 40 subjects with COPD before and after 4 weeks of treatment with inhaled fluticasone (500 µg b.i.d.). Five subjects (12.5 %) with COPD had significant improvement in lung function during fluticasone treatment, while 20 subjects (50 %) had significant decrease in symptoms. High baseline bronchial NO flux was associated with higher increase in FEV1/FVC (r=0.334, p=0.038) and more symptom relief (r =-0.317, p=0.049) during the treatment. Baseline EBC levels of LTB4, cysLTs or 8-isoprostane were not related to response to fluticasone treatment. Inhaled fluticasone decreased bronchial NO flux but not alveolar NO concentration or markers in EBC. High levels of bronchial NO flux are related to symptom relief and improvement of airwa