The Impact of Human Immunodeficiency Virus Type 1 on Infectiousness of Tuberculosis:

To assess if the relative infectiousness of patients with tuberculosis is enhanced by coinfection with human immunodeficiency virus type 1 (HIV-1), data from 6 studies of 1240 health care workers who had contact with tuberculosis patients were analyzed. Overall rates of tuberculin skin test conversion were similar regardless of HIV-1 positivity of tuberculosis patients (odds ratio [OR], 1.04; 95 % confidence interval [CI], 0.23–1.84). However, when only 3 studies during nosocomial outbreaks of multidrug-resistant Mycobacterium tuberculosis were analyzed, rates of skin test conversion were higher among contacts of HIV-1–positive index cases (OR, 2.85; 95 % CI, 1.85–3.85;). A second meta-analysis included data from 11 studies of 10,714 householdPp.0002 contacts of tuberculosis patients. Prevalence of both skin test positivity (OR, 0.45; 95 % CI, 0.20–1.03) and active disease (OR, 1.17; 95 % CI, 0.78–1.56) were similar regardless of HIV-1 positivity of index cases. These data suggest that tuberculosis patients with HIV-1 infection are not intrinsically more infectious to their contacts than are HIV-1–negative tuberculosis patients. In recent years, there has been a marked increase in the number of cases of tuberculosis (TB) reported worldwide [1–4]. This resurgence of TB is largely re-lated to the HIV-1 epidemic. Patients infected wit